葡萄胎曾患者家族癌症史研究

A Study of Family History of Cancer in Wemen with a History of Molar Pregnancy

关键词:  葡萄胎  多基因(或多因子)遗传

Key words:  hydatidiform mole  polygenic (or multifactorial) heredity

摘要:

对1980~1981年间先后两次在广西灵山、钦州及扶绥县农村进行葡萄胎发病调查中获得的141例曾患者家族癌症史有关资料及1983年就葡萄胎曾患者家族癌症史问题在南宁市及其近郊进行的112例专题调查作综合研究。各项调查均同时在每例曾患者的同村庄,同街道,或同一工作单位随机选取1~2例年龄、胎次相当,且无自发流产或死胎史的曾孕妇女作为对照。结果表明,各组曾患者家族癌症史阳性率均高于对照组,以南宁组者为最高,达21.8%(22/101);其中又以一级亲属所占的比例最高,与对照组相比,差异性显著(P<0.05);调查涉及的癌,大多属多基因(或多因子)遗传癌。提出,葡萄胎可能有多基因(或多因子)遗传基础,且与其他多种癌有一部分共同的发病因素。对葡萄胎家族聚集性不明显的可能原因进了简短讨论。

Abstract:

An increase of the frequency of positive family history of cancer in women who had ever had a molar pregnancy was noted during investigations on the incidence of the disease conducted in counties Lingshan and Qinzhou (1980) and Fusui (1982) of Guangxi Zhuang Autonomous Region. Totally 141 molar cases were identified and interviewed with special reference to family history of cancer. The finding was further confirmed in Nanning, the capital of Guangxi, with an even higher frequency (21.8%, 22/101) found and more than two thitds of the family members with cancers of various organs in the molar group were first-degree relatives of the cases and/or their husbands. Controls were randomly selected from the same villege,street or working unit at the same time, at least one for each case. Most of the cancer involved in the investigations bad been reported as polygenic (or multifactorial) ones. we believe that hydatidiform mole would probably also be of a polygenic basis and have a predisposing factor or factors in common with the other polygenic (or multifactorial) cancers. The reasons of why familial aggregation of hydatidiform mole itself had not been very common were briefly discussed.