食用SOD保健品的药理研究

Pharmacologic Studies on SOD Food for Health

关键词:  食用SOD保健品  动物试验  抗衰老

Key words:  SOD food for health  animal experiment  anti-senility

摘要:

6%、3%、1%的供试食用超氧化物歧化酶(SOD)保健品显著延长黑腹果蝇的平均寿命。与蒸馏水比较,15mL/kg可提高老龄小鼠红细胞中SOD的活性,显著降低血清中过氧化脂质含量和对抗氢化可的松所致的小鼠外周血T淋巴细胞脂酶的抑制作用;10mL/kg显著提高正常小鼠腹腔巨噬细胞的吞噬百分率和吞噬指数;15、10mL/kg显著拮抗环磷酰胺所致的巨噬细胞吞噬功能的下降;30、20mL/kg显著延长小鼠的游泳时间。提示供试食用SOD保健品可能有抗衰老作用。试验动物为NIH小鼠和美国野生黑腹果腹(Drosophilamela-nogaster),试验方法为药理学检测方法,供试食用SOD保健品除含主要成分SOD外还含有人参、黄芪、枸杞子等的提取物。

Abstract:

The average longivity of drosophila mela-nogaster was significantly rose up in 6%, 3%,1% superoxide dismutase(SOD) food for health given. The enhancement of activity of SOD in red blood cells of old mice and significant decrement of lipid peroxide of serum and antagonism against inhibition of hytrocortisone to peripheral blood T-lymphocyte esterase of mice were obtained in15 mL/kg as compared with destrilled water. The phagocytosis percentage and index of peritoneal macrophages of normal mice were significantly rose up in 10 mL/kg. The decrement of phagocytosis of peritoneal macrophages caused by cyclophophamide was significantly antagonized in 15 mL/kg and 10 mL/kg. The swimming time of mice is prolongated significantly in 30, 20 mL/kg. Indicating that SOD food for health given may act on anti-senility. The experimental animals were NIH mice and drosophila mela-nogaster and pharmacological methods were used. The SOD food contained the extracts of ginseng, Astragalus membranaceus. Lycium chinense besides SOD.