| 引用本文： |
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杨定华,彭民浩,姜海行,李绍森,卢全书,卢榜裕.p16基因在原发性肝癌中丢失的研究[J].广西科学,1997,4(1):46-47. [点击复制]
- Yang Dinghua,Peng Minhao,Jiang Haixing,Li Shaosheng,Lu Quanshu,Lu Bangyu.On the Loss of p16 Gene in Primary Hepatic Carcinoma[J].Guangxi Sciences,1997,4(1):46-47. [点击复制]
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| 摘要: |
| 为了解抗癌基因p16在原发性肝癌中的变异情况,采用差别PCR技术研究34例原发性肝癌及其癌周组织。结果显示:1例原发性肝癌存在p16Exon1纯合子缺失,15例原发性肝癌存在p16Exon2纯合子缺失,其余的19例肝癌及所有的癌周组织无p16基因纯合子缺失。研究结果表明p16基因的缺失与原发性肝癌的发生发展密切相关,并提供了肝癌第9号染色体基因变异的依据。 |
| 关键词: 原发性肝癌 p16基因 丢失 |
| DOI： |
| 投稿时间：1997-01-17修订日期：1997-01-20 |
| 基金项目: |
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| On the Loss of p16 Gene in Primary Hepatic Carcinoma |
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Yang Dinghua, Peng Minhao, Jiang Haixing, Li Shaosheng, Lu Quanshu, Lu Bangyu
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| (Dept. of General Surgery, First Affiliated Hospital, Guangxi Medical Univ., 6 Binhu Road, Nanning, Guangxi, 530021) |
| Abstract: |
| To determine the alteration of p16,a novel antioncogene, in human primary hepatic carcinoma, 34 cases of primary hepatic carcinoma and tumor-adjacent tissue were examined by Differential PCR.One case was showed as homozygous deletion of p16 Exon1 and 15 cases as homozygus deletion of p16 Exon2.It is indicated that p16 gene deletion is associated with the occuring and development of primary hepatic carcinoma and provides an evidence of gene deletion of chromosome 9p in the human primary hepatic carcinoma. |
| Key words: primary hepatic carcinoma p16 gene loss |
