MVD及VEGF表达与鼻咽癌侵袭转移关系的研究

MVD and the Expression of VEGF Correlate with Invasion and Metastasis of Nasopharyngeal Carcinoma

关键词:  鼻咽肿瘤  血管内皮生长因子  血管生成  肿瘤转移

Key words:  nasopharyngeal neoplasms  vascular endothelial growth factor (VEGF)  angiogenesis  neoplasms invasion and metastasis

摘要:

为探讨微血管密度(MVD)及血管内皮生长因子(VEGF)的表达与鼻咽癌(NPC)侵袭转移关系,在分子水平干预肿瘤血管生成,预防NPC复发和转移打下基础,采用免疫组织化学S-P法检测了73例NPC、15例鼻咽良性肿瘤、20例无瘤鼻咽部石蜡标本组织中的MVD及VEGF表达,NPC中转移组49例,非转移组24例。结果:NPC组织的MVD及VEGF表达显著高于鼻咽良性肿瘤组织及无瘤鼻咽组织的表达(P均<0.01),转移组又较非转移组的表达高(P均<0.05);MVD及VEGF的表达与临床分期相关。结论NPC组织的MVD及VEGF有可能作为判断肿瘤生物学行为、转移潜能及预后指标,对采用血管生成抑制剂防止NPC转移有参考价值。

Abstract:

To study the relationship between microvessel density (MVD) and the expression of vascular endothelial growth factor(VEGF) and invasion and metastasis of nasopharyngeal carcinoma(NPC), explore new approaches to prevent NPC from recurrence and metastasis by inhibiting tumors angiogenesis on the molecule level. MVD and the expression of VEGF were detected using immunohistochemical S-P stainning in Paraffin-embedded specimens include 73 patients with NPC and 15 benign nasopharyngeal tumors, 20 tumor-free nasopharyngeal mucosac,MVD and the expression of VEGF in NPC were higher than that of benign nasopharyngeal tumors and tumor-free mucosac(all P<0.01),metastic carcinomas higher than nonmetastic carcinomas(all P<0.05).The expressions of VEGF and MVD were related to the clinical staging. MVD and expression of VEGF may serve as a parameter for determining tumor biological metastatic potential and prognosis. Angiogenesis inhibitors might be helpful in preventing NPC from metastasis.