天和骨通膏中阿魏酸的体外释药研究

Research on the Ferulic Acid Releasing of Tianhe Gutong in Vitro

关键词:  中药橡皮膏  天和骨通  阿魏酸  体外释药  反相高效液相色谱法

Key words:  Chinese medicine adhesive plaster  Tianhe Gutong  ferulic acid  drug releasing in vitro  RP-HPLC method

摘要:

为研究天和骨通橡皮膏的人体体外释药情况,以阿魏酸含量为考察指标,用反相高效液相法测定贴膏后不同时间的阿魏酸含量,以贴药时间为横坐标,以不同时间揭下膏药中阿魏酸的含量为纵坐标,绘制体外释药曲线。测定结果显示,药物体外释药量随贴药时间的延长而增加,而且能持续释放药物12 h以上。实验表明天和骨通橡皮膏中的药物能从基质中脱离出来并扩散到皮肤或粘膜表面。

Abstract:

To study the drug releasing of Tianhe Gutong adhesive plaster in vitro, the ferulic acid content was determined by RP-HPLC method in different time after the plaster had been stuck. Ferulic acid was used as indicator. A curve of drug releasing in vitro was drawn with a horizontal coordinate for covering time and a longitudinal coordinate for the ferulic acid content at different uncovering time. The drug releasing in vitro increased as the increase of drug covering time, and lasted for over 12 hours. The drug of Tianhe Gutong adhesive plaster can be isolated from substrate and spread to the surface of skin as well as mucosa.