| 引用本文： |
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苏桂发,万红敬,查丹明,牟红涛.微波辐射相转移催化合成环丙烷氨基酸[J].广西科学,2001,8(4):279-280,283. [点击复制]
- Su Guifa,Wan Hongjing,Zha Danming,Mu Hongtao.Synthesis of 1-Aminocyclopropanecarboxylic Acid under Microwave Irradiation and Phase Transfer Catalysis[J].Guangxi Sciences,2001,8(4):279-280,283. [点击复制]
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| 摘要: |
| 以KOH-K2CO3作碱,Al2O3为外浴,以四丁基溴化铵(TBAB)为相转移催化剂,采用微波辐射干反应技术实现醛亚胺Ph CH=NCH2CO2 Et与1,2-二溴乙烷的串联烷基化反应。最佳反应条件为:醛亚胺3mmol,二溴乙烷5.7mm ol,TBAB 0.6 mmol,KOH 7mm ol,K2CO3 14mmol,以Al2O3作外浴,微波辐射功率240W,微波辐射时间1min,产率56%。 |
| 关键词: 微波辐射 相转移催化 无溶剂反应 环丙烷氨基酸 醛亚胺 烷基化 |
| DOI： |
| 投稿时间：2001-07-23修订日期：2001-08-29 |
| 基金项目:广西自然科学基金资助项目(桂科自9811025)。 |
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| Synthesis of 1-Aminocyclopropanecarboxylic Acid under Microwave Irradiation and Phase Transfer Catalysis |
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Su Guifa, Wan Hongjing, Zha Danming, Mu Hongtao
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| (Dept of Chem & Chemical Eng, Guangxi Normal Univ, 3 Yucailu, Guilin, Guangxi, 541004, China) |
| Abstract: |
| The synthesis of 1-Aminocyclopropanecarboxylic Acid(ACC) was performed by tandem alkylation of 1,2-dibromoethane and ethyl N-(phenylmethylene) glycinate under solvent-free condition coupled with microwave irradiation and phase transfer catalysis. The optimum reaction conditions are as follows:an external alumina bath is used, aldimine 3 mmol, 1,2-dibromoethane 5.7 mmol, TBAB 0.6 mmol, KOH 7 mmol, K2CO3 14 mmol, microwave power 240 W and 1 min of microwave irradiation. The production rate is 56%. |
| Key words: microwave irradiation phase transfer catalysis solvent-free reaction 1-aminocyclopropanecarboxylic acid aldimine alkylation |
