二苯甲酰甲烷席夫碱过渡金属配合物的制备及仿酶催化活性研究

Synthesis and Catalytic Activity of Mimics of Enzymes of Schiff Base Complexes Derived from Dibenzoylmethide 2-amin-3-phenyl-propionic Acid and Ion of Transition Metal

关键词:  配合物  席夫碱  二苯甲酰甲烷  过氧化氢  仿酶催化

Key words:  complexes  Schiff-base  dibenzoylmethide  hydrogen peroxide  mimic enzyme

摘要:

利用溶液法合成二苯甲酰甲烷席夫碱过渡金属配合物,用紫外、红外、热重分析方法对目标产物进行结构表征与确认,以过氧化氢残余率为指标,分析催化剂种类、催化剂与过氧化氢配比、反应温度、溶液酸度对催化反应的影响,研究该配合物作为模拟过氧化氢酶,对过氧化氢分解的催化性能。结果确定出配合物仿酶催化剂催化分解过氧化氢反应的最佳条件为:二苯甲酰甲烷缩苯丙氨酸席夫碱镍配合物催化性能最好,当其浓度为1.0×10^-5mol/L时,控制过氧化氢浓度为0.05mol/L,温度55℃,溶液的pH值为8。配合物仿酶催化剂催化分解过氧化氢反应符合一级反应特征。

Abstract:

The Schiff base complexes derived from dibenzoylmethide 2-amin-3-phenyl-propionic acid and ion of transition metal ion were synthesized by the solution method, and its structure were confirmed by modern analysis test method such as ultraviolet, infrared, TG analysis and so on.Using the remnant rate of hydrogen peroxide in solution as the target, the affect of the catalyst type, the proportion of catalyst and hydrogen peroxide, the reaction temperature, and the solution acidity on the catalytic reaction were studied, and the optimum of decomposition reaction of hydrogen peroxide were determined under catalyst of mimics of enzymes of Schiff base complexes.The results showed that the optimums are the Schiff base complexes from dibenzoylmethide 2-amin-3-phenyl-propionic acid and ion of nickel of 1.0×10^-5 mol/L, reaction temperature of 55℃, the concentration of hydrogen peroxide solution of 0.05mol/L, and the solution pH value of 8.The catalytic reaction mechanism was discussed for initially and the reaction was proved to be firstorder dynamis reaction as catalyst of mimics of enzfmes of the complexes.