生物酶法合成1,5-戊二胺的研究进展

Research Progress of the Biosynthesis of 1, 5-Diaminopentane

关键词:  1, 5-戊二胺  赖氨酸脱羧酶  大肠杆菌  谷氨酸棒状杆菌  甲醇芽孢杆菌

Key words:  1, 5-diaminopentane  lysine decarboxylase  Escherichia coli  Corynebacterium glutamicum  Bacillus methanolicus

摘要:

随着经济的飞速发展,全球每年对聚酰胺、聚氨酯等多聚物产品的需求量呈现逐年增长的趋势。1,5-戊二胺是合成聚酰胺等多聚物的重要单体,生物法合成1,5-戊二胺是一种具有潜在竞争力的绿色环保、资源可持续利用的方法。本文将从代谢途径中的关键酶,大肠杆菌、谷氨酸棒状杆菌以及甲醇芽孢杆菌中戊二胺代谢途径工程改造的最新研究进展4个方面进行综述,并对其前景进行展望。

Abstract:

With the rapid development of global economy, the requirements for polyamide, polyurethane and other polymer products are increasing annually. 1, 5-Diaminopentane is an important chemical monomer to synthetize polymer, such as polymides and polyurethane. Biosynthesis of 1, 5-diaminopentane is of potential competitiveness, sustainable and also friendly to environment. In this paper, the latest research progress of the functions of key enzymes in metabolic pathway, 1, 5-diaminopentane in Escherichia coli, Corynebacterium glutamicum, Bacillus methanolicus are reviewed and the prospect is forecasted.