烟曲霉细胞壁作为药物靶标的鉴定研究

Identification of Aspergillus fumigatus Cell Wall as an Anti-fungal Target

关键词:  烟曲霉  细胞壁  葡聚糖  几丁质  药物靶标

Key words:  Aspergillus fumigatus  cell wall  glucan  chitin  drug target

摘要:

烟曲霉(Aspergillus fumigatus)作为侵袭性真菌感染的三大机会病原真菌之一,因其高致病率和高致死率而成为威胁人类健康的重大隐患。有限的抗真菌类药物以及近年来耐药性菌株的涌现使得寻找新的药物靶标并开发新型抗真菌药物迫在眉睫。真菌细胞壁作为真菌所特有的结构一直以来被认为是理想的药物靶标。本文概述了烟曲霉细胞壁结构及合成过程的相关研究进展,并分析了参与细胞壁各组分合成的酶作为药靶的可行性。

Abstract:

Aspergillus fumigatus is one of the three opportunistic fungal pathogens causing invasive fungal infections. Due to high morbidity and high mortality this fungus imposes life-threatening hazard to human health. Limited anti-fungal drugs and recently emerging resistant strains urge the unmet need for new anti-fungal targets and new drugs.Cell wall as the unique structure for fungi has been considered as the ideal drug target. Here we overview the structure and biosynthesis of A.fumigatus cell wall, and analyze the feasibility of those enzymes involved in cell wall synthesis as drug target.