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潘丽霞,朱婧,王青艳,杨登峰.细胞色素P450酶生物转化及新催化反应的最新进展[J].广西科学,2018,25(3):258-261. [点击复制]
- PAN Lixia,ZHU Jing,WANG Qingyan,YANG Dengfeng.The Latest Advance of Biotransformation and New Catalytic Reaction of Cytochrome P450 Enzymes[J].Guangxi Sciences,2018,25(3):258-261. [点击复制]
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| 细胞色素P450酶生物转化及新催化反应的最新进展 |
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潘丽霞1, 朱婧1, 王青艳1, 杨登峰2
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| (1.广西科学院, 非粮生物质酶解国家重点实验室, 国家非粮生物质能源工程技术研究中心, 广西生物质产业化工程院, 广西生物炼制重点实验室, 广西南宁 530007;2.广西科学院, 广西北部湾海洋研究中心, 广西海洋天然产物与组合合成生物化学重点实验室, 广西南宁 530007) |
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| 摘要: |
| 细胞色素P450酶(P450s或CYPs)是一类广泛存在于生命体中,依赖于亚铁血红素催化多种底物的单加氧酶。一方面,它涉及许多高活性天然产物生物合成的关键步骤,对其生物转化研究有助于提高活性分子的产率和活性;另一方面,其催化涉及金属元素以及辅助因子,其蛋白质改造和新催化反应的研发也不断取得新突破。本文就细胞色素P450酶这两方面的最近研究进展进行了总结与论述。 |
| 关键词: 酶工程 细胞色素P450酶 生物转化 新催化反应 |
| DOI：10.13656/j.cnki.gxkx.20180522.002 |
| 投稿时间：2018-04-24 |
| 基金项目:国家自然科学基金项目(31660251)和广西自然科学基金项目(2017GXNSFAA198010)资助 |
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| The Latest Advance of Biotransformation and New Catalytic Reaction of Cytochrome P450 Enzymes |
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PAN Lixia1, ZHU Jing1, WANG Qingyan1, YANG Dengfeng2
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| (1.State Key Laboratory of Non-Food Biomass and Enzyme Technology, National Engineering Research Center of Non-food Biorefinery, Guangxi Biomass Industrialization Engineering Institute, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China;2.Guangxi Beibu Gulf Marine Research Center, Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Academy of Sciences, Nanning, Guangxi, 530007, China) |
| Abstract: |
| Cytochrome P450 enzymes (P450s or CYPs) are a widespread large super family of mono-oxygenase that catalyzes the different substrates via heme in life beings.On the one hand, P450s involves in the key step of high-active natural product biosynthetic pathway, its biotransformation studies will help to increase the yield and activity of active molecules.On the other hand, its catalysis involves in metal elements and cofactors, new breakthroughs have been made in the protein modification and new catalytic reaction of P450s.In this article the latest advances in these two aspects of cytochrome P450 enzymes have been summarized and discussed. |
| Key words: enzyme engineering cytochrome P450 enzymes biotransformation new catalytic reaction |
