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韦棪婷,郝二伟,夏中尚,蒋秋燕,杜正彩,邓家刚,侯小涛.厚藤提取物对胶原诱导关节炎模型大鼠的治疗作用研究[J].广西科学,2021,28(6):626-633. [点击复制]
- WEI Yanting,HAO Erwei,XIA Zhongshang,JIANG Qiuyan,DU Zhengcai,DENG Jiagang,HOU Xiaotao.Study on the Therapeutic Effect of Ipomoea pes-caprae Extract on Collagen-induced Arthritis Model Rats[J].Guangxi Sciences,2021,28(6):626-633. [点击复制]
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| 厚藤提取物对胶原诱导关节炎模型大鼠的治疗作用研究 |
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韦棪婷1,2, 郝二伟2, 夏中尚2,3, 蒋秋燕1, 杜正彩2, 邓家刚2, 侯小涛1,2
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| (1.广西中医药大学药学院, 广西南宁 530200;2.广西中医药大学, 广西中药药效研究重点实验室, 广西南宁 530200;3.成都中医药大学药学院, 四川成都 611137) |
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| 摘要: |
| 为探究厚藤（Ipomoea pes-caprae）提取物对胶原诱导关节炎（Collagen-induced Arthritis，CIA）模型大鼠的治疗作用，本研究采用牛Ⅱ型胶原诱导建立CIA大鼠模型，观察厚藤提取物高、中、低剂量组（2.271 2，1.135 6，0.567 8 g/kg）对CIA大鼠踝关节肿胀、足跖肿胀、关节炎症评分、踝关节病理切片及血清中前列腺素E2（Prostaglandin E2，PGE2）、类风湿因子（Rheumatoid Factor，RF）、C-反应蛋白（C-reactive Protein，CRP）表达水平的影响。结果表明：与模型组相比，给药干预后，踝关节肿胀度、足跖肿胀度有减轻趋势但无显著性差异（P>0.05）；厚藤提取物高、中剂量组能显著降低关节炎症指数、PGE2、CRP水平（P<0.05，P<0.01）；厚藤提取物各剂量组均能显著降低RF水平（P<0.01）。踝关节病理切片结果显示，厚藤提取物高、中剂量组病变程度相比于模型组均得到减轻。综上可知，厚藤提取物对CIA大鼠具有较好的治疗作用，能减轻关节肿胀、缓解滑膜炎症状，这可能与减少PGE2、RF、CRP表达有关。 |
| 关键词: 厚藤 提取物 类风湿性关节炎 前列腺素E2 类风湿因子 C-反应蛋白 |
| DOI：10.13656/j.cnki.gxkx.20220117.001 |
| 投稿时间：2021-06-10 |
| 基金项目:广西一流学科建设项目重点课题（2018XK043），广西中医药大学校级一般硕士研究生科研创新项目（YCSY2020026），中国-东盟传统药物研究国际合作联合实验室建设（二期）（桂科AD19110155），广西中药药效研究重点实验室运行补助项目（20-065-38）和广西高等学校高水平创新团队及卓越学者计划（2019-52）资助。 |
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| Study on the Therapeutic Effect of Ipomoea pes-caprae Extract on Collagen-induced Arthritis Model Rats |
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WEI Yanting1,2, HAO Erwei2, XIA Zhongshang2,3, JIANG Qiuyan1, DU Zhengcai2, DENG Jiagang2, HOU Xiaotao1,2
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| (1.Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, China;2.Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530200, China;3.Faculty of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, China) |
| Abstract: |
| In order to explore the therapeutic effect of Ipomoea pes-caprae extracts (IPE) on collagen-induced arthritis (CIA) model rats,CIA rat model was established by bovine type Ⅱ collagen in this study.The effects of high,medium and low doses of I.pes-caprae extracts (2.271 2,1.135 6,0.567 8 g/kg) on the ankle swelling,footpad swelling,joint inflammation score,pathological section of ankle joint and serum prostaglandin E2 (PGE2),rheumatoid factor (RF),C-reactive protein (CRP) expression levels of CIA rats were observed.The results showed that compared with the model group,the ankle swelling degree and plantar swelling degree showed a decreasing trend but no significant difference after administration intervention (P>0.05).Moreover,the high-dose and medium-dose IPE groups could significantly reduce the joint inflammation index,PGE2 and CRP levels (P<0.05,P<0.01).RF levels were significantly decreased in each dose of groups (P<0.01).The pathological section results of the ankle joint showed that the pathological changes in the high-dose and medium-dose IPE groups were both alleviated compared with the model group.In conclusion,I.pes-caprae extracts has significant therapeutic effect on CIA rats,which can relieve joint swelling and synovial inflammation symptoms,which may be related to the reduction of PGE2,RF and CRP expression. |
| Key words: Ipomoea pes-caprae extract rheumatoid arthritis PGE2 RF CRP |
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