组蛋白修饰与癫痫的发生发展研究进展

Research Progress of Histone Modification and the Occurrence and Development of Epilepsy

关键词:  癫痫  表观遗传学  组蛋白修饰  组蛋白乙酰化与甲基化  JMJD6

Key words:  epilepsy  epigenetics  histone modification  histone acetylation and methylation  JMJD6

摘要:

癫痫是由脑部神经元异常同步或过度放电导致的一种慢性脑部疾病。在神经系统疾病中，癫痫已成为仅次于脑血管病的第二大严重威胁人类健康的疾病，且其发病机制至今未明。表观遗传机制是调节基因表达的一种方式，其中组蛋白修饰是主要的表观遗传修饰之一。组蛋白修饰的异常与癫痫的发生发展密切相关，本文对组蛋白修饰与癫痫的关系进行综述，以期从组蛋白修饰的角度阐明两者之间的关系，为癫痫的防治提供新思路。

Abstract:

Epilepsy is a chronic brain disorder caused by abnormal synchronization or excessive discharge of neurons in the brain. In nervous system diseases, epilepsy has become the second largest serious threat to human health after cerebrovascular diseases, and its pathogenesis has not yet been understood. Epigenetic mechanism is a way to regulate gene expression, and histone modification is one of the main epigenetic modifications. Abnormal histone modifications are closely related to the occurrence and development of epilepsy. The relationship between histone modification and epilepsy is reviewed in this article to clarify the relationship between them from the perspective of histone modification and provide new ideas for the prevention and treatment of epilepsy.