| 引用本文： |
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陶慧林,寿红娟,朱仕毅.3种黄酮类小分子与牛血清白蛋白间相互作用及其构效关系的研究[J].广西科学院学报,2010,26(3):338-342. [点击复制]
- TAO Hui-lin,SHOU Hong-juan,ZHU Shi-yi.Study of Interaction and Structure-Activity Relation-ships between Three Flavonoids and BSA[J].Journal of Guangxi Academy of Sciences,2010,26(3):338-342. [点击复制]
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| 摘要: |
| 解析3种黄酮类小分子桑色素(MOR)、槲皮素(QUE)、芦丁(RUT)与牛血清白蛋白(BSA)相互作用后的紫外-可见光谱和荧光猝灭光谱,研究在同一实验条件下黄酮类小分子与BSA的相互作用及其构效关系。结果显示,黄酮母核B环上的羟基处于相邻位置时,比处于其他位置时表现出的BSA猝灭作用和结合作用更强,而有较大取代基团存在时,由于位阻较大,黄酮类小分子与BSA间的猝灭作用及结合作用则明显变弱。 |
| 关键词: 黄酮 牛血清蛋白 相互作用 构效关系 |
| DOI： |
| 投稿时间：2010-06-20 |
| 基金项目:广西教育厅科研项目(No.200708LX339)资助。 |
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| Study of Interaction and Structure-Activity Relation-ships between Three Flavonoids and BSA |
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TAO Hui-lin, SHOU Hong-juan, ZHU Shi-yi
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| (Department of Chemistry and Biological Engineering, Guilin University of Technology, Guilin, Guangxi, 541004, China) |
| Abstract: |
| The structure-activity relationship and interaction between three flavonoids including Morin(MOR),Quercetin(QUE) and Rutin(RUT) and BSA were observed by UV-visible spectra and fluorescence quenching spectra.The results showed that the quenching and binding effect between flavonoids and BSA were strong when the.hydroxyl group was in the adjacent position of B benzene ring of nucleus.However,the quenching and binding effect between flavonoids and BSA decreased when a large group existed,which is due to the steric hindrances. |
| Key words: flavonoids bovine serum albumin interaction structure-activity relationships |
