南宁地区肝细胞性肝癌中突变型p53蛋白表达

p53 Mutation Protein ExPrssion in Hepatocellular Carcinoma in Nanning District

关键词:  p⁵³蛋白  肝细胞性肝癌  黄曲霉毒素B₁

Key words:  p⁵³ Protein  hepatocellular carcinoma  aflatoxin

摘要:

用ABC免疫组织化学方法,对南宁地区居民中13例肝细胞性肝癌(HCC)的活检组织进行研究。发现其中8例有突变型p⁵³蛋白呈强阳性表达,占HCC病例数64.3%。南宁地区某些县,如扶绥县是我国著名的HCC高发区,不但HBV感染率高,而且是全国少有的AFB₁高污染区,后者的作用不能忽视。与江苏启东和南部非洲HCC高发区一样,估计也会出现p⁵³基因突变热点。

Abstract:

Immunohistochemistry ABC method was used to study 13 biopsy casses of hepatocellular carcinoma (HCC) in Nanning prefectural district. Eight cases (64.3%) were found to have positive expression of p⁵³ mutation protein. Fu-Sui and its surrounding counties in the district are notorious for their high HCC incidence in China, not only high in infection of hepatitis B Verus (HBV) but also high in contamination of aflatoxin B₁ (AFB₁), and both are putative risk factors of HCC. The AFB₁ could injure the DNA and cause a mutational hot spot in the p⁵³ gene. Thus its effect should not be neglected.