慢性阻塞性肺疾病痰白细胞介素-16的测定及其意义

Significance of Detecting Interleukin-16 in Induced Sputum from Patiens with Chronic Obstructive Pulmonary Disease

关键词:  慢性阻塞性肺疾病  白细胞介素-16  气道炎症

Key words:  chronic obstructive pulmonary disease  interleukin-16  airway inflammation

摘要:

收集19例急性期慢性阻塞性肺疾病(COPD)患者,6例COPD缓解期患者以及10例正常对照者的痰液,以酶联免疫吸附法(ELISA)测定其痰液白细胞介素16(IL16)水平,以探讨IL16在COPD发病机制中的作用及其对COPD气道炎症的临床意义。结果,COPD患者急性发作期痰IL16水平(1233±492.44ng/L)和缓解期(1232±513.53ng/L)均明显高于正常对照者(660.77±312.11ng/L)(P<0.05)。此外,COPD患者痰液IL16水平与FEVl呈负相关(r=-0.43,P<0.05)。以上结果表明,IL16参与了COPD气道炎症的发病过程,其机制可能与激活T淋巴细跑有关。

Abstract:

In order to explore the role of interleukin-16(IL-16) in the pathogenesis of chronic obstructive pulmonary disease(COPD), and to evaluate the clinical values of IL-16 in the airway inflammation of COPD, IL-16 levels of induced sputum from 19 patients with acute COPD, 6 patients with stable COPD and 10 normal subjects were detected by ELISA method. The results showed that IL-16 levels of induced sputum in patients with acute COPD (1233±492.44 ng/L) and with stable COPD(1232±513.53 ng/L) were much higher than that in normal subjects(660.77±312.11 ng/L) (P<0.05). In addition, there was a negative correlation between IL-16 of induced sputum and FEV1 (r=-0.43,P<0.05).Our findings indicate that IL-16 could be involved in the airway inflammation process of COPD by activating T lymphocytes.