贻贝防卫素的研究进展

Progress of Research on Mussel Defensins

关键词:  贻贝  防卫素  抗微生物肽  先天免疫  海洋软体动物

Key words:  mussel  defensin  antimicrobial peptide  innate immunity  marine mollusea

摘要:

防卫素是贻贝等海洋软体动物的重要抗微生物肽,迄今发现的贻贝防卫素根据其初级结构、性质和共有的半胱氨酸列阵分成:贻贝防卫素(MDA和MDB)、地中海贻贝防卫素(MGD1和MGD2)、Myticins (MyticinA和Myticin B)、Mytilins (Mytilin A,Mytilin B,Mytilin C,Mytilin D和Mytilin G1)和Mytim ycin。阐述它们的化学性质、结构、产生和生物活性等。不同环境中的贻贝不易为重病所折磨,能抵御各类微生物的入侵和保卫自身,对贻贝防卫素的研究有助于人们理解贻贝及其他海洋软体动物的先天免疫并提高海水养殖的水平。

Abstract:

Defensins contained in mussel and other marine mollusca are important antimicrobial peptides.The mussel defensins known update are divided into four groups according to character,primary structure and mutual cysteine sequence.They are mytilus defensins(MDA and MDB),Mytilus gallovoprovincial defensins (MGD1 and MGD2);Myticins A and B;Mytilins A,B,C,D,G1;and Mytimycin.Their chemical character and structure,production and bioactivities are explained.The mussels living in various environments are not subjected to serious diseases,and resist invading of diverse pathogens and protect themselves from enemy microbials.The researches on mussel defensins are contribute to understand of the innate immunity of mussel and other marine mollusea,and improvement of maricultural techniques.