| 摘要: |
| 本文综述了黄嘌呤氧化酶(XOD)的研究进展及其发展前景。首先总结了XOD的基因、蛋白结构、催化机制和生物合成机制,其次介绍了与XOD催化相关的嘌呤代谢途径及其生理病理作用和相关的疾病,再次综述了目前已有商品化XOD及其生产现状和存在的问题,然后概述了XOD的应用进展和发展前景,最后探讨了XOD基础和应用研究存在的问题并提出发展建议。 |
| 关键词: 黄嘌呤氧化酶 酶生物合成及其调控 辅助装配 代谢途径 低嘌呤食品 检测试剂盒 细胞工厂 |
| DOI：10.13656/j.cnki.gxkx.20170116.001 |
| 投稿时间：2017-01-09 |
| 基金项目:国家自然科学基金青年科学基金项目(21406132),中国博士后科学基金面上项目(2014M550743)和中国博士后科学基金特别资助项目(2015T80094)资助 |
|
| Research Progress and Prospects of Xanthine Oxidase |
|
WANG Chenghua1,2, XING Xinhui2,3
|
| (1.College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi, 530004, China;2.MOE Key Laboratory of Industrial Biocatalysis, Institute of Biochemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing, 100084, China;3.Center for Synthetic and Systems Biology, Tsinghua University, Beijing, 100084, China) |
| Abstract: |
| This review comprehensively summarizes the research progresses and future prospects in both the basic and application studies of xanthine oxidase (XOD).The achievements, progresses and prospects for XOD study are systematically presented in five aspects:1) gene, protein, catalytic mechanism and biosynthesis process; 2) metabolic pathway, physiological roles and pathological effects relating to XOD, and diseases caused by abnormity of XOD; 3) production status and existing problems of commercial XODs; 4) progress and future prospects of XOD applications; 5) suggestions for future research prospects. |
| Key words: xanthine oxidase enzyme biosynthesis and regulation auxiliary assembly metabolic pathway low purine food diagnostic kit cell factory |
