岩藻黄素降脂活性及其作用机制研究进展

Research Progress on Lipid Lowering Activity and Mechanism of Fucoxanthin

关键词:  岩藻黄素  类胡萝卜素  抗肥胖  生物活性  作用机制

Key words:  fucoxanthin  carotenoid  anti-obesity  bioactivity  mechanism of action

摘要:

岩藻黄素（Fucoxanthin）是海洋褐藻中主要的叶黄素类类胡萝卜素，也是褐藻中主要的降脂活性成分之一。岩藻黄素具有抗肿瘤、抗炎症、抗肥胖等多种生物活性，在代谢调节方面，岩藻黄素能促进脂肪分解和脂肪酸氧化，上调白色脂肪组织中线粒体解偶联蛋白1（UCP1）的表达，具有显著的抗肥胖功效，但其具体作用机制还需要进一步研究。本文综述近年来岩藻黄素在促进前体脂肪细胞分化、诱导白色脂肪细胞棕色化、调节胆固醇代谢等方面作用机制的研究成果，为进一步研究岩藻黄素的降脂作用机制提供理论参考。

Abstract:

Fucoxanthin is the main lutein carotenoid and one of the main lipid-lowering active components in brown algae,which has many biological activities such as anti-tumor,anti-inflammation and anti-obesity.In terms of metabolic regulation,fucoxanthin can promote fat decomposition,fat acid oxidation and up-regulate the expression of mitochondrial uncoupling protein (UCP1) in white fat tissue,and has a significant anti-obesity effect.However,its specific mechanism needs further study.In this paper,the research results on the mechanism of fucoxanthin in promoting the differentiation of pre-adipocytes,inducing the browning of white adipocytes,and regulating cholesterol metabolism in recent years were summarized,so as to provide theoretical reference for further research on lipid-lowering mechanism of fucoxanthin.