酵母耐高温分子机制的研究进展

Research Progress on Molecular Mechanism of Thermo-tolerance in Yeast

关键词:  酵母  耐高温  代谢途径  基因表达  热激蛋白

Key words:  yeast  thermo-tolerance  metabolic pathway  gene expression  heat shock protein

摘要:

耐高温是酵母在工业生产中的重要特性之一。近年来，人们对耐高温酵母的应用研究日益重视并取得较大的进展，但其耐高温分子机制尚未明确。目前的研究结果表明，酵母耐高温机制涉及代谢网络调控、信号转导途径及多基因/蛋白共同作用等方面。本文从代谢途径、基因表达、酶活特性和蛋白质相互作用等4个方面综述当前酵母耐高温分子机制的研究进展，为酵母耐热性能的基因工程定向改造提供理论依据。

Abstract:

Thermo-tolerance is one of the important characteristics of yeast in industrial production.In recent years, more and more attentions have been paid to the application of thermo-tolerant yeast and great progress has been made, but the molecular mechanism of thermo-tolerance has not been clearly explained.The current research results indicated that the mechanism of yeast thermo-tolerance involved metabolic network regulation, signal transduction pathway and the interaction of multiple genes/proteins.In this article, the current research progress on molecular mechanisms of thermo-tolerance in yeast is reviewed from four aspects, including metabolic pathways, gene expression, characteristics of enzyme activity and protein interactions, which will provide a theoretical basis for rational design and improvement of yeast heat resistance and reduction of industrial production cost.