南海疣状柳珊瑚中八放二萜类化学成分研究

Study on Briarane-type Diterpenoids of Gorgonian Coral Verrucella umbraculum from South China Sea

关键词:  珊瑚  疣状柳珊瑚  化学成分  结构鉴定

Key words:  corals  Verrucella umbraculum  chemical constituents  structure elucidation

摘要:

[目的]为了证明疣状柳珊瑚(Verrucella umbraculum)中的主要化学成分是八放二萜类化合物,并获得结构新颖的八放二萜类化合物。[方法]采用硅胶柱色谱、Sephadex LH-20和反相半制备HPLC等方法分离化合物,根据波谱数据以及文献对照方法,确定其结构。[结果]从疣状柳珊瑚分离得到10个八放二萜类化合物,鉴定为junceellin A(1)、renillafoulin A(2)、praelolide(3)、(-)-11α,20α-epoxy-4-deacetyljunceellolide(4)、umbraculolide A(5)、umbraculolide C(6)、junceellolide A(7)、13-deacetylnui-inoalide A(8)、erythrolide T(9)、erythrolide U(10)。[结论]化合物3~10为首次从疣状柳珊瑚中分离得到,丰富了该属柳珊瑚中的化学成分类型。

Abstract:

[Objective] To prove that the prime chemical components of Gorgonian Coral Verrucella umbraculum are briarane-type diterpenoids and Verrucella umbraculum from the South China Sea is used to isolate some new briarane-type diterpenoids.[Methods] The compounds were isolated and purified by silica gel, Sephadex LH-20,and semi-preparative reverse-phase HPLC(C₁₈).Their structures were identified by their spectral data.[Results] Ten compounds were isolated from Verrucella umbraculum and their structures were identified as junceellin A(1); renillafoulin A(2); praelolide(3);(-)-11α,20α-epoxy-4-deacetyljunceellolide(4); umbraculolide A(5); umbraculolide C(6);junceellolide A(7); 13-deacetylnui-inoalide A(8); erythrolide T(9); erythrolide U(10).[Conclusion] Compounds 3~10 were isolated from Verrucella umbraculum for the first time, which not only enriched the types of chemical composition in the genus gorgonian, but also increase the research value of the genus gorgonian.