真菌感染防控及真菌细胞壁靶标的研究进展

Research Progress in Prevention and Control of Fungal Infections and Fungal Cell Wall Targets

关键词:  真菌感染  真菌病害  药物靶标  细胞壁  抗真菌药

Key words:  fungal infection  fungal disease  drug target  cell wall  antifungal drugs

摘要:

全球有超过10亿人患有真菌感染，每年有超过160万人因此而死亡，且真菌感染病例正呈激增趋势。此外，真菌病害不仅严重影响作物的生长，还会产生毒素影响农作物的质量，对农业生产带来严重影响。真菌的细胞壁结构在哺乳动物中不存在，且与植物细胞壁组分完全不同，因此成为开发抗真菌药物的理想靶标。本文详细阐述病原真菌对人类、动物和植物的风险，临床和农业上使用的抗真菌药物，以及真菌细胞壁不同组分在药物研发中的研究进展，并展望基于广西的天然资源在抗真菌药物研发中的潜在前景。

Abstract:

More than 1 billion people worldwide are affected by fungal infection.More than 1.6 million people die each year, and the cases of fungal infection are increasing rapidly.In addition, fungal diseases not only seriously affect the growth of crops, but also affect the quality of crops through the production of toxins, which has a serious impact on agricultural production.The cell wall structure of fungi does not exist in mammals and is completely different from the cell wall components of plants, so it is an ideal target for the development of antifungal drugs.In this article, the risk of pathogenic fungi to humans, animals and plants, antifungal drugs used in clinic and agriculture, and the research progress on different components of fungal cell wall in drug development are described in detail.And the potential prospects of natural resources based on Guangxi in the development of antifungal drugs are prospected.