饮用水的诱变性与肝癌的风险

Mutagenicity of Drinking Water and Liver Cancer Risk

关键词:  饮用水  诱变性试验  蚕豆根尖微核  肝肿瘤

Key words:  drinking water  mutagenicity test  micronucleus of the root tips of Vicia faba  liver neoplasms

摘要:

应用蚕豆根尖微核技术研究了肝癌高发区扶绥县饮用水的诱变性与肝癌发病的关系。结果表明,检测32份不同饮水类型的饮用水(饮用塘水、塘边井水、井水、河水和自来水)中有12份饮用塘水和2份塘边井水能明显诱导蚕豆根尖微核率增高(P<0.01),而井水、河水和自来水所诱发的蚕豆根尖微核率与对照组则无显著差异(P>0.05)。提示该县饮用塘水中存在染色体畸变的物质,此类物质在各种饮水类型的水样中所诱发的蚕豆根尖微核效应与当地居民肝癌发病率呈正相关关系(r=0.86P<0.05)。表明摄入这些化学诱变剂可能是导致肝癌高发的危险因素之一。

Abstract:

A relationship between mutagenic activity of drinking water and incidence of liver cancer was studied in Fusui county, a high liver cancer incidence area in China, by micronucleus technique in the root tips of Victa faba. Results showed that among 32 samples of different kinds of drinking water (drinking pond water, well-water by the ponds, well-water, the water of the river and tap water) there existed 12 samples of drinking pond water and 2 samples of well-water by the ponds that induced the increment of micronuclear frequences (P<0.01), while there was no difference of the micronuclear frequences between the well-water, river water or tap water and that of the contrast group (P>0.05). It suggested that there existed a substance that caused chromosome aberration in the drinking pond water of Fusui county. Micronucleus effects from a substance in different kinds of drinking water coincided with the incidence of liver cancer (r=0.86,P<0.05).The ingestion of these chemical mutagens from the water may be one of the important factors that caused high incidence of human liver cancer.