| 引用本文： |
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符诗聪,罗仕华,周玲珠,张凤华.木芙蓉叶有效组分对大鼠肾缺血再灌注损伤的保护作用[J].广西科学,2004,11(2):131-133. [点击复制]
- Fu Shicong,Luo Shihua,Zhou Lingzhu,Zhang Fenghua.Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model[J].Guangxi Sciences,2004,11(2):131-133. [点击复制]
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| 摘要: |
| 为了探讨木芙蓉叶有效组分(MFR)对大鼠肾缺血再灌注损伤中的作用,采用大鼠肾缺血再灌注模型,木芙蓉叶有效组分灌胃给药,观察血清尿素氮(BUN)、肌酐(Scr)及肾组织病理变化,并检测白细胞介素-1(IL-1)的含量。结果再灌注24h后,治疗组血BUN及Scr明显降低(P<0.05);治疗组血液IL-1含量与非治疗组相比有显著性差异(P<0.05);而且治疗组肾组织病理损伤较非治疗组明显减轻。木芙蓉叶有效组分对肾缺血再灌注损伤有保护作用,其原因可能与抑制IL-1等的生成有关 |
| 关键词: 有效组分 木芙蓉叶 肾缺血再灌注 血清尿素氮 肌酐 白细胞介素-1 |
| DOI： |
| 投稿时间：2003-11-19修订日期：2004-03-01 |
| 基金项目:本课题为上海市教委资助重点课题(课题编号:01B11)。 |
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| Effect of Leaves of Hibiscus mutabilis L.on Renal Ischemia Reperfusion Injury of Rat Model |
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Fu Shicong1, Luo Shihua1, Zhou Lingzhu2, Zhang Fenghua1
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| (1.Dept of Traumatology, Ruijin Hospital, SSMU, 197 Ruijin Erlu, Shanghai, 200025, China;2.Dept. of Ruijin Hospital, SSMU, 197 Ruijin Erlu, Shanghai, 200025, China) |
| Abstract: |
| To explore the role of effective fraction of Hibiscus mutabilis L. (MFR) on renal ischemia reperfusion injury in rat. Using a model of renal ischemia reperfusion injury,determined the change of blood urea nitrogen (BUN),serum creatinine(Scr),the pathological change of kidney tissue and the level of interleukin 1(IL-1) after the Hibiscus mutabilis L. was administrated.Results At 24 h after reperfusion,the BUN and Scr level decreased significantly in MFR group (P<0.05). The level of IL-1 was marked difference between MFR group and blank group (P<0.05). The renal pathological injury of MFR group was mitigated significantly The results suggest that Hibiscus mutabilis L. protects kidney from ischemia-reperfusion injury,and that this action may underline its inhibitory action on the interleukin-1 releasing. |
| Key words: effective fraction leaves of Hibiscus mutabilis L. renal ischemia reperfusion blood urea nitrogen serum creatinine interleukin-1 |
